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首页> 外文期刊>Journal of drug delivery science and technology >Skin microporation: Strategies to enhance and expand transdermal drug delivery
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Skin microporation: Strategies to enhance and expand transdermal drug delivery

机译：皮肤微穿孔：增强和扩大透皮给药的策略

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摘要

Transdermal therapies have been known and used by many cultures over the centuries. The modern age of transdermal drug delivery started with the marketing of Transderm Scōp in 1979 as a scopolamine patch for the treatment of motion sickness, nausea and vomiting. Since 1997, transdermal drug delivery companies have aligned with life science and biopharmaceutical industries, to deliver large molecules, peptides and proteins, i.e. insulin, calcitonin, PTH (1-34), etc. Strategies and technologies have been developed for skin pretreatment or continuous use, in order to accomplish large molecule delivery. So far, the most effective strategy for overcoming the skin's barrier properties has been to focus on the creation of micropores in the stratum corneum. Microchannels or micropores can be created by external means such as microneedles, ultrasound, electroporation, radiofrequency and laser. Strategies and methods are now being developed to characterize micropores and understand their viability. Additionally, approaches to enhancing micropore lifetime are being investigated. The key to future successes in transdermal drug delivery of large molecules, especially biopharmaceuticals, will be the understanding and maintenance of skin micropores generated by microneedle pretreatment or other external physical techniques.
机译：几个世纪以来，透皮疗法已为许多文化所熟知和使用。透皮给药的现代时代始于1979年TransdermScōp的市场营销，它是一种东pol碱贴剂，用于治疗晕车，恶心和呕吐。自1997年以来，透皮给药公司已与生命科学和生物制药行业保持一致，以输送大分子，肽和蛋白质，例如胰岛素，降钙素，PTH（1-34）等。已经开发了用于皮肤预处理或连续性治疗的策略和技术。使用，以完成大分子传递。迄今为止，克服皮肤屏障特性的最有效策略是集中于在角质层中形成微孔。微通道或微孔可以通过外部方式产生，例如微针，超声，电穿孔，射频和激光。现在正在开发表征微孔并了解其生存能力的策略和方法。另外，正在研究提高微孔寿命的方法。大分子（尤其是生物制药）的透皮给药的未来成功的关键将是理解和维护由微针预处理或其他外部物理技术产生的皮肤微孔。

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