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首页> 外文期刊>Hepato-gastroenterology. >The choice of surgical timing for biliary duct reconstruction after obstructive bile duct injury: An experimental study
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The choice of surgical timing for biliary duct reconstruction after obstructive bile duct injury: An experimental study

机译：梗阻性胆管损伤后胆管重建手术时机的选择：一项实验研究

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Background/Aims: The surgical time of obstructive bile duct injury when biliary-enteric reconstruction is needed remains controversial till now. Methodology: Sixty dogs models of bile duct injury were established and divided into six groups according, to the days (0, 5, 10, 15, 20, 30 days) of injury. At the time of surgery, biopsy was taken and Roux-en-Y hepaticojejunostomy was performed. The morphology and local histopathology of bile duct, the liver function in different periods were observed. Surgical complications and survival were also evaluated. Results: In the early time (5-10 days), the proximal bile ducts dilated continuously and showed acute inflammation change, but slow in the later period (10-30 days). Moreover, the bile duct wall gradually transformed into fibroplasias from the inflammatory edema after 10 days. During the development of jaundice, the liver function was damaged, especially after 20 days. After reconstructing, the bile leakages in the groups that repaired within 10 days were more than the ones in other groups (7 vs. 3, p <0.05), and the malnutrition or organ failure occurring in 3 months was most at the 30-day group (n = 7, p <0.05). Conclusions: The period between 10 and 20 days after bile duct obstruction may be optimal for surgical repair.
机译：背景/目的：迄今为止，需要进行胆肠-肠重建术时梗阻性胆管损伤的手术时间仍存在争议。方法：建立60只狗的胆管损伤模型，并根据受伤天数（0、5、10、15、20、30天）将其分为六组。手术时进行活检，并进行Roux-en-Y肝空肠吻合术。观察不同时期胆管的形态学和局部组织病理学，肝功能。还评估了手术并发症和生存率。结果：在早期（5-10天），近端胆管持续扩张并显示出急性炎症变化，但在后期（10-30天）变慢。而且，胆管壁在10天后从炎性水肿逐渐转变为纤维化。在黄疸发展期间，肝功能受损，尤其是在20天后。重建后，在10天之内修复的组中的胆汁渗漏要比其他组的多（7 vs. 3，p <0.05），并且在3个月内发生的营养不良或器官衰竭最多在30天内组（n = 7，p <0.05）。结论：胆管阻塞后10至20天可能是手术修复的最佳时间。

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