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Microfluidic Microsphere-Trap Arrays for Simultaneous Detection of Multiple Targets

机译：同时检测多个目标的微流控微球捕获阵列

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摘要

Microsphere arrays can be used to effectively detect, identify, and quantify biological targets, such as mRNAs, proteins, antibodies, and cells. In this work, we design a microfluidic microsphere-trap array device that enables simultaneous, efficient, and accurate screening of multiple targets on a single platform. Different types of targets are captured on the surfaces of microspheres of different sizes. By optimizing the geometric parameters of the traps, the trap arrays in this device can immobilize microspheres of different sizes at different regions with microfluidic hydrodynamic trapping. The targets are thus detected according to the microspheres' positions (position-encoding), which simplifies screening and avoids errors in target identification. We validate the design using fluid dynamics finite element simulations by COMSOL Multiphysics software using microsphere of two different sizes. We also performed preliminary microsphere-trapping experiments on a fabricated device using microspheres of one size. Our results demonstrate that the proposed device can achieve the position-encoding of the microspheres with few fluidic errors. This device is promising for simultaneous detection of multiple targets and become a cheap and fast disease diagnostic tool.
机译：微球阵列可用于有效检测，鉴定和定量生物靶标，例如mRNA，蛋白质，抗体和细胞。在这项工作中，我们设计了一种微流体微球阱阵列设备，该设备能够在单个平台上同时，高效和准确地筛选多个目标。在不同大小的微球表面上捕获不同类型的目标。通过优化捕集阱的几何参数，该装置中的捕集阱阵列可以通过微流体流体动力捕集在不同区域固定大小不同的微球。因此，根据微球的位置检测目标（位置编码），这简化了筛选并避免了目标识别中的错误。我们使用两种不同尺寸的微球体通过COMSOL Multiphysics软件进行的流体动力学有限元模拟来验证设计。我们还使用一种尺寸的微球在制造的设备上进行了初步的微球捕获实验。我们的结果表明，所提出的装置可以实现微球的位置编码而几乎没有流体误差。该设备有望用于同时检测多个目标，并成为一种便宜而快速的疾病诊断工具。

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  • 来源
    《Microfluidics, bioMEMS, and medical microsystems XI》|2013年|86151E.1-86151E.11|共11页
  • 会议地点 San Francisco CA(US)
  • 作者

    Xiaoxiao Xu; Zhenyu Li; Nalinikanth Kotagiri; Pinaki Sarder; Samuel Achilefu; Arye Nehorai;

  • 作者单位

    Preston M. Green Department of Electrical and Systems Engineering, Washington University in St.Louis, St. Louis, MO 63130, USA;

    Department of Electrical and Computer Engineering, The George Washington University,Washington, D.C., 20052, USA;

    The Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis,St. Louis, MO 63110, USA;

    The Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis,St. Louis, MO 63110, USA;

    The Mallinckrodt Institute of Radiology, Washington University School of Medicine in St. Louis,St. Louis, MO 63110, USA;

    Preston M. Green Department of Electrical and Systems Engineering, Washington University in St.Louis, St. Louis, MO 63130, USA;

  • 会议组织
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Microfluidics; Microsphere-Trap Arrays; Simultaneous Detection of Multiple Targets;

    机译：微流体；微球捕获阵列；同时检测多个目标;

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