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Clinical outcomes of combined versus separate carbachol and brimonidine drops in correcting presbyopia

机译：卡巴胆碱和溴莫尼定滴眼液联合或单独滴眼液在矫正老花眼中的临床效果

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Background To test and compare in a masked fashion the efficacy of using a parasympathomimetic drug (3% carbachol) and an alpha-2 agonist (0.2% brimonidine) in both combined and separate forms to create optically beneficial miosis to pharmacologically improve vision in presbyopia. Methods A prospective, double-masked, randomized, controlled clinical trial was conducted. Ten naturally emmetropic and presbyopic subjects between 42 and 58?years old with uncorrected distance visual acuity of at least 20/20 in both eyes without additional ocular pathology were eligible for inclusion. All subjects received 3% carbachol and 0.2% brimonidine in both combined and separate forms, 3% carbachol alone and 0.2% brimonidine (control) alone in their non-dominant eye in a crossover manner with one week washout between tests. The subjects’ pupil sizes and both near and distance visual acuities will be evaluated pre- and post-treatment at 1, 2, 4, and 8?h, by a masked examiner at the same room illumination. Results Statistically significant improvement in mean near visual acuity (NVA) was achieved in all subjects who received combined 3% carbachol and 0.2% brimonidine in the same formula compared with those who received separate forms or carbachol alone or brimonidine alone ( P
机译：背景技术为了以掩盖方式测试和比较使用拟副交感神经药（3％卡巴胆碱）和α-2激动剂（0.2％溴莫尼定）的组合形式和单独形式的功效，以产生光学有益的瞳孔缩小，以药理作用改善老花眼的视力。方法进行了一项前瞻性，双重掩蔽，随机对照研究。十名年龄在42至58岁之间的自然正视眼和老花眼受试者，其双眼的未矫正远视力至少为20/20，且没有其他眼部病理，因此符合纳入标准。所有受试者在他们的非优势眼中以交叉方式接受了3％的卡巴胆碱和0.2％的溴莫尼定，单独和单独的3％的卡巴胆碱和0.2％的溴莫尼定（对照组），并在两次试验之间进行了一周的冲洗。在相同的室内照明条件下，将由一名戴面具的检查员在1、2、4和8？h时对受试者的瞳孔大小以及近，远视力进行评估。结果与分别接受单独形式或单用卡巴胆碱或溴莫尼定的受试者相比，接受相同配方的3％卡巴胆碱和0.2％溴莫尼定的所有受试者的平均近视力（NVA）均有统计学上的显着改善（P <？0.0001） 。结论根据数据，该组合溶液比其他经过测试的溶液显示出更高的功效。通过使瞳孔变小来提高焦深，可在统计学上显着改善近视力，而双目远距视力没有变化。试用注册ACTRN12616001565437。 2016年11月11日注册。

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