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首页> 美国卫生研究院文献>Current Controlled Trials in Cardiovascular Medicine >Aspirin and Simvastatin Combination for Cardiovascular Events Prevention Trial in Diabetes (ACCEPT-D): design of a randomized study of the efficacy of low-dose aspirin in the prevention of cardiovascular events in subjects with diabetes mellitus treated with statins
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Aspirin and Simvastatin Combination for Cardiovascular Events Prevention Trial in Diabetes (ACCEPT-D): design of a randomized study of the efficacy of low-dose aspirin in the prevention of cardiovascular events in subjects with diabetes mellitus treated with statins

机译：阿司匹林和辛伐他汀联合用于糖尿病的心血管事件预防试验（ACCEPT-D）：一项低剂量阿司匹林在他汀类药物治疗的糖尿病患者中预防心血管事件功效的随机研究设计

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BackgroundDespite the high cardiovascular risk, evidence of efficacy of preventive strategies in individuals with diabetes is scant. In particular, recommendations on the use of aspirin in patients with diabetes mostly reflect an extrapolation from data deriving from other high risk populations. Furthermore, the putative additive effects of aspirin and statins in diabetes remain to be investigated. This aspect is of particular interest in the light of the existing debate regarding the need of multiple interventions to reduce total cardiovascular risk, which has also led to the proposal of a polypill. Aim of the study is to evaluate the efficacy of aspirin in the primary prevention of major cardiovascular events in diabetic patients candidate for treatment with statins. These preventive strategies will be evaluated on the top of the other strategies aimed at optimizing the care of diabetic patients in terms of metabolic control and control of the other cardiovascular risk factors.
机译：背景尽管心血管疾病的风险很高，但对糖尿病患者采取预防策略的有效性的证据很少。特别是，有关在糖尿病患者中使用阿司匹林的建议主要反映了从其他高风险人群获得的数据进行的推断。此外，阿司匹林和他汀类药物在糖尿病中的假定加性作用尚待研究。鉴于有关需要采取多种干预措施以降低总心血管风险的现有辩论，这方面尤其令人感兴趣，这也导致了多药丸的提议。该研究的目的是评估阿司匹林在主要预防他汀类药物治疗的糖尿病患者重大心血管事件中的功效。这些预防策略将在其他策略的顶部进行评估，这些策略旨在通过代谢控制和其他心血管风险因素的控制来优化糖尿病患者的护理。

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